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KMID : 0363320070280020304
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Journal of Korean Oriental Internal Medicine
2007 Volume.28 No. 2 p.304 ~ p.320
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Effect of Astragalus Membranaceus Extract against Improvement of Myelosuppression and Quality of Life in 5-Fluorouracil Treated Mice
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Kwon Chang-Hyun
Yoo Hwa-Seung
Bang Sun-Hwi
Lee Young-Min
Lee Yeon-Weol
Son Chang-Gue
Cho Chong-Kwan
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Abstract
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Objective : To evaluate the effect of Astragalus Membranaceus Extrac (AME) on myelosuppression, activity and immune modulation in 5-fluorouracil (5-FU) treated mice.
Method : We carried out complete blood count, histological analysis of bone marrow, and cell colony forming assay for hematopoietic progenitor to evaluate the effect of AME on myelosuppression and conducted swimming test, survival rate, nitric oxide (NO) assay, 51Cr release assay in natural killer cell, mRNA expression of IL-1{beta}, IL-2, IL-4, IL-6, IL-10, TNF-{alpht}, IFN-{gamma}, TGF-{beta} and GM-CSF in spleen cells to evaluate the effect of AME on quality of life (QOL).
Results : AME improved 5-FU induced myelosuppression and peripheral blood count was recovered effectively, had significant efficacy to protect against chemotherapy induced marrow-destruction and on hematopoiesis compared with the control group, improved increase survival rate and the swimming time, had a stimulatory effect on macrophage activation and NK cell activity, and up-regulated cytokine gene transcription (IL-2, IL-6, IFN-{gamma}) in murine immunologic system.
Conclusion : We can conclude that AM is an effective herbal agent for improvement of myelosuppression and QOL in 5-FU treated mice.
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KEYWORD
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Astragalus Membranaceus, Myelosuppression, Quality of Life, 5-Fluorouracil
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